Chemerin reveals its chimeric nature

Chemerin reveals its chimeric nature

Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antii...

Dark Matter: Its Nature

survive its chimerical nature ?

69 Commentary Can chiropractic survive its chimerical nature? " The only way to avoid the slippery slope is to stay off the slope ". If we were to compare the profession of chiropractic to creatures of legend, in its early days chiropractic was like a hydra, whose practitioners possessed a 'body' of core beliefs and practice patterns but a rather contentious leadership , one with many 'heads'. ...

Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature

Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane-bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in Bacillus subtilis. In this work we describe the Bacillus cereus SpoIIS system which is a three-component system, harboring an additional gene sp...

POX 186 : the ultracompact blue compact dwarf galaxy reveals its nature ?

High resolution, ground based R and I band observations of the ultra compact dwarf galaxy POX 186 are presented. The data, obtained with the ESO New Technology Telescope (NTT), are analyzed using a new deconvolution algorithm which allows one to resolve the innermost regions of this stellar-like object into three Super-Star Clusters (SSC). Upper limits to both masses (M∼ 10 5 M) and physical si...